Designer DNA Nanoarchitectures

Rational design of DNA nanoarchitectures.

DNA has many physical and chemical properties that make it a powerful material for molecular constructions at the nanometer length scale. In particular, its ability to form duplexes and other secondary structures through predictable nucleotide-sequence-directed hybridization allows for the design of programmable structural motifs which can self-assemble to form large supramolecular arrays, scaf...

Multifunctional nanoarchitectures from DNA-based ABC monomers.

The ability to attach different functional moieties to a molecular building block could lead to applications in nanoelectronics, nanophotonics, intelligent sensing and drug delivery. The building unit needs to be both multivalent and anisotropic, and although many anisotropic building blocks have been created, these have not been universally applicable. Recently, DNA has been used to generate v...

Designer DNA Architectures for Bionanotechnology

DNA tile based self-assembly: building complex nanoarchitectures.

DNA tile based self-assembly provides an attractive route to create nanoarchitectures of programmable patterns. It also offers excellent scaffolds for directed self-assembly of nanometer-scale materials, ranging from nanoparticles to proteins, with potential applications in constructing nanoelectronic/nanophotonic devices and protein/ligand nanoarrays. This Review first summarizes the currently...

Subtractive assembly of DNA nanoarchitectures driven by fuel strand displacement.

Herein we demonstrate that flexible DNA architectures with larger cavities can be efficiently constructed by first assembling a relatively more rigid DNA tile architecture and subsequently subtracting a center tile through fuel strand displacement; such structures are otherwise difficult to obtain if the center tile is missing in the beginning, proving a new strategy for DNA self-assembly.